Cisplatin induced aki

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WebMar 23, 2024 · For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10-20% of all cancer patients. Although nephrotoxicity associated with platinum-based agents is well recognized, treatment of cisplatin-induced acute kidney injury is mainly su … WebMar 29, 2024 · Administration of the chemotherapeutic agent cisplatin leads to acute kidney injury (AKI). Cisplatin-induced AKI (CIAKI) has a complex pathophysiological map, which has been linked to cellular uptake and efflux, apoptosis, vascular injury, oxidative and endoplasmic reticulum stress, and inflammation …

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WebOct 15, 2024 · Cisplatin administration for acute kidney injury (AKI) leads to serious side effects and there is a higher risk of death [2]. In clinical practice, the main causes of AKI are infections, nephrotoxic drugs, diabetes, hypertension, sepsis and cardiovascular disease. WebPrevention of Cisplatin-Induced Acute Kidney Injury: A Systematic Review and Meta-Analysis Prevention of Cisplatin-Induced Acute Kidney Injury: A Systematic Review and Meta-Analysis Authors founder inn and spa direct phone number

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WebApr 25, 2014 · After a single dose of cisplatin (50–100 mg/m2), approximately one-third of the patients develop nephrotoxicity [10, 11]. An improved knowledge of the … WebAug 30, 2024 · Cisplatin-induced AKI is dose dependent and thereby limits the dose of drug that can be used . In comparison, hepatotoxicity can occur only when cisplatin is administered at high doses . Thus, cisplatin-induced AKI is considered one of the major side-effects of cisplatin therapy. Although some procedures including hydration … founder in horse hoof

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WebFeb 3, 2024 · Cisplatin, a widely used anticancer agent, can cause nephrotoxicity, including both acute kidney injury (AKI) and chronic kidney diseases, by accumulating in renal tubular epithelial cells (TECs). Mitochondrial pathology plays an important role in the pathogenesis of AKI. Based on the regulatory role of transcription factor EB (TFEB) in … WebDec 12, 2024 · Cisplatin can induce AKI through ischemic damage, by reducing the blood flow in the medulla of the kidneys leading to tubular cell injury. Vasoconstriction due to … founder in hindiWebOct 13, 2024 · Cisplatin-induced acute kidney injury (AKI), characterized by rapid loss of renal function within days of initiating treatment, occurs in around 30% of patients who are receiving cisplatin ... disadvantages of silica fume in concrete

"WebCisplatin (cis-diamminedichloroplatinum (II), DDP) is an antineoplastic agent widely used in the treatment of solid tumors because of its extensive cytotoxic activity. However, the … " - Cisplatin induced aki

Cisplatin induced aki

HIPEC-Induced Acute Kidney Injury: A Retrospective Clinical

WebFeb 24, 2024 · Generally, several factors, such as ischemia, insufficiency of the circulating blood volume, nephrotoxic drugs, and urinary tract obstruction, lead to AKI. Apart from blood purification, there are few effective treatments for AKI. Untreated AKI would continue to cause further damage and is associated with a poor prognosis. WebJan 29, 2024 · Fig. 1: Cisplatin induced Renal injury were alleviated by Ferroptosis inhibitor Ferrostatin-1 (Fer-1). A, B Serum BUN and Cr levels of each group at 48 h and 72 h after cisplatin injection....

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WebSep 25, 2015 · Purpose Acute kidney injury (AKI) is a common and serious adverse effect of cisplatin-based chemotherapy. However, traditional markers of kidney function, such as serum creatinine, are suboptimal, because they are not sensitive measures of proximal tubular injury. We aimed to determine whether the new urinary biomarkers such as … WebDec 16, 2024 · Cisplatin induces acute ischemic injury, resulting in decreased renal medullary blood flow ( 24) and renal tubular cell damage ( 25 ). Meanwhile, cisplatin can block calcium ion channels to reduce COX-2 and prostaglandin, cause vasoconstriction, and eventually lead to aggravation of hypoxia ( 26 ).

WebNational Center for Biotechnology Information WebAug 6, 2014 · A known complication of cisplatin administration is acute kidney injury (AKI). The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often necessitates dose reduction or withdrawal. Recurrent episodes of AKI may result in chronic kidney disease.

WebOct 1, 2024 · Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer. However, its dose-limiting side effect is nephrotoxicity leading to acute kidney injury (AKI). Patients who develop AKI have an increased risk of mortality and are more likely to develop chronic kidney disease (CKD). WebJan 3, 2024 · Cisplatin nephrotoxicity; Classic Kaposi sarcoma: Clinical features, staging, diagnosis, and treatment; Contrast-associated and contrast-induced acute kidney injury: Clinical features, diagnosis, and management; Crystal-induced acute kidney injury; Dosing of anticancer agents in adults; Drug reaction with eosinophilia and systemic …

WebApr 6, 2015 · Drug-induced AKI, as observed during cisplatin-based anticancer therapy, is responsible for about 20% of renal failure cases. The initial injury triggers a proliferative response in renal tubular cells, which in the presence of cellular damage can further accelerate renal injury.

WebCisplatin-induced AKI typically occurs 5–7 days after therapy, whereas dialysis-requiring AKI is uncommon in the absence of concomitant nephrotoxic exposures. AKI typically resolves within a few weeks, but progressive CKD … founder inn abd spa direct phobe numberWebJun 17, 2024 · A cisplatin-induced AKI mice model was established by administering 22 mg/kg cisplatin to both WT and Tet2 -KO mice to investigate the role of Tet2. It was observed that the Scr and BUN levels... disadvantages of sign languageWebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in … founder in mini horsesWebMar 13, 2024 · Background Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the … disadvantages of single entry systemWebAug 6, 2014 · A known complication of cisplatin administration is acute kidney injury (AKI). The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often … disadvantages of silk pillowcasesWebAug 1, 2024 · A mouse model of cisplatin-induced AKI was established as described previously. After 10 mg/kg cisplatin (Sigma-Aldrich, USA, P4394) intraperitoneal injection for 72 h, Neu-NVs, hucMSC-sEVs, and NEX with the same particle number were administered to the AKI mice by tail vein for 2 consecutive days. founder in ponies treatmentWebJan 18, 2024 · Background Early detection and prediction of cisplatin-induced acute kidney injury (Cis-AKI) are essential for the management of patients on chemotherapy with cisplatin. This study aimed to evaluate the performance of a prediction model for Cis-AKI. Methods Japanese patients, who received cisplatin as the first-line chemotherapy at … disadvantages of simple sphere model